Melissa Magstadt, South Dakota Secretary of Health
South Dakota Department of Health

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Your health: COVID-19 information & resources


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South Dakota COVID-19 Information Line.
Questions about COVID-19? We're here to help.
Please Call: 1-800-997-2880

Precautions to Avoid Illness

Prevention Actions for All COVID-19 Community Levels

In addition to basic health and hygiene practices, like handwashing, some prevention actions are recommended at all COVID-19 Community Levels, including:

Resources & Information

RELEASED 08-11-2022: CDC streamlines COVID-19 guidance to help the public better protect themselves and understand their risk (CDC)

Answers to Tough Questions about Public Health (Public Health Communications Collaborative)

Use and Care of Masks (CDC)

What You Need to Know About Variants (CDC)

Pregnant Women and New Parents

Cleaning and Disinfection Recommendations

Immunocompromised or at High Risk

COVID-19 Community Level

Check your COVID-19 Community Level - If you or your family member are at high risk for severe illness, wear a mask or respirator with greater protection in public indoor spaces if you are in an area with a high COVID-19 Community Level. Talk with your healthcare provider about wearing a mask in a medium COVID-19 Community Level.

COVID-19 Preventive Medication

Evusheld is an investigational medicine that can help protect you from getting COVID-19. You may be eligible for Evusheld if you:

  • Are moderately or severely immunocompromised and may not mount an adequate immune response to COVID-19 vaccination OR have a history of severe allergic reactions to COVID-19 vaccines, and

  • Do not currently have COVID-19 and have not recently had close contact with someone with COVID-19, and

  • Are an adult or adolescent ages 12 years and older weighing at least 88 pounds (40 kg).

Evusheld contains two different antibodies that can help prevent COVID-19. It must be given by your healthcare provider before exposure to COVID-19.

Talk to your healthcare provider to find out if this option is right for you. Even if you receive Evusheld, taking multiple prevention steps, such as wearing a well-fitting mask or respirator and avoiding crowded places, can provide additional layers of protection from COVID-19.

Treatment Available

If you test positive and are an older adult or someone who is at high risk of getting very sick from COVID-19, treatment may be available. Contact a healthcare provider right away after a positive test to determine if you are eligible, even if your symptoms are mild right now. You can also visit a Test to Treat location and, if eligible, receive a prescription from a provider. Don't delay: Treatment must be started within the first few days to be effective.

COVID-19 Treatments and Medications

For people who are more likely to get very sick from COVID-19 infection, medications are available that can reduce the chances of severe illness and death. Other medications can help reduce symptoms and help manage the illness.

People who are more likely to get very sick include older adults (ages 50 years or more, with risk increasing with older age), people who are unvaccinated, and people with certain medical conditions, such as a weakened immune system.

Being vaccinated makes you much less likely to get very sick. Still, some vaccinated people, especially those ages 65 years or older or who have other risk factors for severe disease, may benefit from treatment if they get COVID-19. A healthcare provider will help decide which treatment, if any, is right for each individual.

The FDA has issued emergency use authorizations (EUA) for certain antiviral medications and monoclonal antibodies to treat mild to moderate COVID-19 in people who are more likely to get very sick. Learn more.

Quarantine, Isolation, & Self-Monitoring

Symptoms of COVID-19

  • Fever or chills

  • Cough

  • Shortness of breath or difficulty breathing

  • Fatigue

  • Muscle or body aches

  • Headache

  • New loss of taste or smell

  • Sore throat

  • Congestion or runny nose

  • Nausea or vomiting

  • Diarrhea


When to Isolate

Regardless of vaccination status, you should isolate from others when you have COVID-19. You should also isolate if you are sick and suspect that you have COVID-19 but do not yet have test results. If your results are positive, follow the full isolation recommendations found here. If your results are negative, you can end your isolation.

CDC streamlines COVID-19 guidance to help the public better protect themselves and understand their risk

RELEASED 08-11-2022

  • Key Guidance - view CDC's news release with all of the updates

    • Recommending that instead of quarantining if you were exposed to COVID-19, you wear a high-quality mask for 10 days and get tested on day 5.

    • Recommending that if you test positive for COVID-19, you stay home for at least 5 days and isolate from others in your home.  You are likely most infectious during these first 5 days. Wear a high-quality mask when you must be around others at home and in public.

      • If after 5 days you are fever-free for 24 hours without the use of medication, and your symptoms are improving, or you never had symptoms, you may end isolation after day 5.

      • Regardless of when you end isolation, avoid being around people who are more likely to get very sick from COVID-19 until at least day 11.

      • You should wear a high-quality mask through day 10.

    • Recommending that if you had moderate illness (if you experienced shortness of breath or had difficulty breathing) or severe illness (you were hospitalized) due to COVID-19 or you have a weakened immune system, you need to isolate through day 10.

    • Clarifying that after you have ended isolation, if your COVID-19 symptoms worsen, restart your isolation at day 0. Talk to a healthcare provider if you have questions about your symptoms or when to end isolation.

Resources & Information

Treatment & Theraputics

Learn about COVID-19 Treatment options

Monoclonal Antibody Treatments

The U.S. Food and Drug Administration issued an Emergency Use Authorization to allow the use of monoclonal antibodies for the treatment of mild to moderate symptoms of COVID-19 in adults and pediatric patients.

View South Dakota Monoclonal Antibody Treatment flyer

What are monoclonal antibodies? Monoclonal antibodies are laboratory-made proteins that mimic the antibodies created by your immune system to fight off harmful viruses. Bamlanivimab + etesevimab and casirivimab + imdevimab are monoclonal antibodies that are specifically designed to protect against severe COVID-19 infection. The antibodies bind to the spike protein of the COVID-19 virus to stop the virus from entering your cells and continuing the infection.

  • Who can get this treatment? Antibody treatment can be used by people with mild to moderate COVID-19 who:
    • Test positive for SARS-CoV-2;
    • Are within 10 days of the start of their symptoms;
    • Are age 12 or older and weigh at least 88 pounds; and
    • Are at high risk of progressing to severe COVID-19 infection or of needing to be admitted to a hospital because of COVID-19. Examples of chronic medical conditions include:
      • Chronic kidney disease
      • Diabetes
      • Immunosuppressive disease
      • Currently receiving immunosuppressive treatment
      • Having a body mass index (BMI) greater than 25 (overweight or obese)
      • Pregnancy
      • Aged 65 years and older
      • Cardiovascular disease (including congenital heart disease) or hypertension
      • Chronic lung diseases (e.g., chronic obstructive pulmonary disease [COPD], asthma [moderate-to-severe], interstitial lung disease, cystic fibrosis, and pulmonary hypertension)
      • Sickle cell disease
      • Neurodevelopmental disorders (e.g., cerebral palsy) or other complex conditions (e.g., genetic or metabolic syndromes and severe congenital abnormalities)
      • Having a medical-related technological dependence (e.g, tracheostomy, gastrostomy, or positive pressure ventilation [not related to COVID-19])

Individuals who meet high risk criteria and test positive should contact their primary care physician about a referral for antibody treatment within three days of a positive test result and no later than 10 days after symptom onset.

Treatment for COVID-19 available in many parts of the state. Check with your health care provider about the use of monoclonal antibodies or an antiviral.

These medications will be available at no cost to patients, although health care facilities may charge for administering the medicine.

Covid-19 Monoclonal Antibody Therapeutics Locations Map.

Avera Health

  • Avera St. Luke’s Hospital - Aberdeen
  • Avera Dells Area Hospital - Dell Rapids
  • Avera De Smet Memorial Hospital - De Smet
  • Avera Flandreau Hospital - Flandreau
  • Freeman Regional Hospital - Freeman
  • Avera Gregory Hospital - Gregory
  • Avera Milbank Area Hospital - Milbank
  • Avera Hand Co. Memorial Hospital - Miller
  • Avera Queen of Peace Hospital - Mitchell
  • Avera St Benedict Hospital - Parkston
  • Avera St. Mary’s Hospital - Pierre
  • Avera Platte Health Center - Platte
  • Community Memorial Hospital - Redfield
  • Avera Landmann-Jungman Memorial Hospital - Scotland
  • Avera St. Michael’s Hospital -Tyndall
  • Avera Wagner Community Hospital - Wagner
  • Avera Sacred Heart Hospital - Yankton

Monument Health

  • Monument Health Custer Hospital - Custer
  • Monument Health Lead-Deadwood Hospital - Deadwood
  • Philip Health Services - Philip
  • Monument Health Rapid City Hospital - Rapid City
  • Monument Health Spearfish Hospital - Spearfish
  • Monument Health Sturgis Hospital - Sturgis

Sanford Health

  • Sanford Aberdeen Medical Center - Aberdeen
  • Douglas Co Memorial Hospital - Armour
  • Community Memorial Hospital - Burke
  • Sanford Canton-Inwood Medical Center - Canton
  • Sanford Chamberlain Medical Center - Chamberlain
  • Sanford Clear Lake Medical Center - Clear Lake
  • Sanford USD Medical Center - Sioux Falls
  • Sanford Vermillion Medical Center - Vermillion
  • Pioneer Memorial Hospital - Viborg
  • Sanford Webster Medical Center - Webster
  • Winner Regional Hospital - Winner

Independent Hospitals

  • Bowdle Hospital - Bowdle
  • Brookings Health System – Brookings
  • Faulkton Area Medical Center - Faulkton
  • Fall River Health Services - Hot Springs
  • Huron Regional Healthcare Center - Huron
  • Madison Community Hospital - Madison
  • Bennett Co Hospital - Martin
  • Mobridge Regional Hospital - Mobridge
  • Oyate Health Center - Rapid City
  • Prairie Lakes Healthcare System - Watertown
Behavioral Health Plasma Donation

Everyone plays a part in getting through the COVID-19 pandemic. If you have fully recovered from COVID-19, you may be able to help patients currently fighting the infection by donating your plasma, also known as convalescent plasma. Because you fought the infection, your plasma now contains COVID-19 antibodies. These antibodies provided one way for your immune system to fight the virus when you were sick, so your plasma may be able to help others fight off the disease.

To become a convalescent plasma donor, individuals should contact their physician or visit the websites below for more information:

Individuals or family members who are interested in acquiring a donation for a family member should contact their clinician for more information.

MultisystemInflammatory Syndrom (MIS-C)

What is MIS-C?

Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. We do not yet know what causes MIS-C. However, many children with MIS-C had the virus that causes COVID-19, or had been around someone with COVID-19. More information is available on CDC’s website.

MIS-C in South Dakota

Total Cases: 6
Locations: 3 from East River; 3 from West River
Sex of Cases: 3 female; 3 male
Age of Cases: 6 in the 0-17 year age group
Outcomes: 6 (100%) hospitalized; Zero (0%) died

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