COVID-19 information and resources for the public on precautions to avoid illness, vaccines, symptoms, treatments, and therapeutics.

  • Fever or chills

  • Cough

  • Shortness of breath or difficulty breathing

  • Fatigue

  • Muscle or body aches

  • Headache

  • New loss of taste or smell

  • Sore throat

  • Congestion or runny nose

  • Nausea or vomiting

  • Diarrhea



COVID-19 vaccine recommendations have been updated as of February 28, 2024, to recommend adults ages 65 years and over receive an additional updated 2023-2024 COVID-19 vaccine dose.

The U.S. Food and Drug Administration issued an Emergency Use Authorization to allow the use of monoclonal antibodies for the treatment of mild to moderate symptoms of COVID-19 in adults and pediatric patients.

View the South Dakota Monoclonal Antibody Treatment flyer

What are monoclonal antibodies? Monoclonal antibodies are laboratory-made proteins that mimic the antibodies created by your immune system to fight off harmful viruses. Bamlanivimab + etesevimab and casirivimab + imdevimab are monoclonal antibodies that are specifically designed to protect against severe COVID-19 infection. The antibodies bind to the spike protein of the COVID-19 virus to stop the virus from entering your cells and continuing the infection.

  • Who can get this treatment? Antibody treatment can be used by people with mild to moderate COVID-19 who:
    • Test positive for SARS-CoV-2;
    • Are within 10 days of the start of their symptoms;
    • Are age 12 or older and weigh at least 88 pounds; and
    • Are at high risk of progressing to severe COVID-19 infection or of needing to be admitted to a hospital because of COVID-19. Examples of chronic medical conditions include:
      • Chronic kidney disease
      • Diabetes
      • Immunosuppressive disease
      • Currently receiving immunosuppressive treatment
      • Having a body mass index (BMI) greater than 25 (overweight or obese)
      • Pregnancy
      • Aged 65 years and older
      • Cardiovascular disease (including congenital heart disease) or hypertension
      • Chronic lung diseases (e.g., chronic obstructive pulmonary disease [COPD], asthma [moderate-to-severe], interstitial lung disease, cystic fibrosis, and pulmonary hypertension)
      • Sickle cell disease
      • Neurodevelopmental disorders (e.g., cerebral palsy) or other complex conditions (e.g., genetic or metabolic syndromes and severe congenital abnormalities)
      • Having a medical-related technological dependence (e.g, tracheostomy, gastrostomy, or positive pressure ventilation [not related to COVID-19])

Individuals who meet high-risk criteria and test positive should contact their primary care physician about a referral for antibody treatment within three days of a positive test result and no later than 10 days after symptom onset.

Treatment for COVID-19 is available in many parts of the state. Check with your healthcare provider about the use of monoclonal antibodies or an antiviral.

COVID-19 Monoclonal Antibody Therapeutics Locations

Avera Health
  • Avera St. Luke’s Hospital - Aberdeen
  • Avera Dells Area Hospital - Dell Rapids
  • Avera De Smet Memorial Hospital - De Smet
  • Avera Flandreau Hospital - Flandreau
  • Freeman Regional Hospital - Freeman
  • Avera Gregory Hospital - Gregory
  • Avera Milbank Area Hospital - Milbank
  • Avera Hand Co. Memorial Hospital - Miller
  • Avera Queen of Peace Hospital - Mitchell
  • Avera St Benedict Hospital - Parkston
  • Avera St. Mary’s Hospital - Pierre
  • Avera Platte Health Center - Platte
  • Community Memorial Hospital - Redfield
  • Avera Landmann-Jungman Memorial Hospital - Scotland
  • Avera St. Michael’s Hospital -Tyndall
  • Avera Wagner Community Hospital - Wagner
  • Avera Sacred Heart Hospital - Yankton
Monument Health
  • Monument Health Custer Hospital - Custer
  • Monument Health Lead-Deadwood Hospital - Deadwood
  • Philip Health Services - Philip
  • Monument Health Rapid City Hospital - Rapid City
  • Monument Health Spearfish Hospital - Spearfish
  • Monument Health Sturgis Hospital - Sturgis
Sanford Health
  • Sanford Aberdeen Medical Center - Aberdeen
  • Douglas Co Memorial Hospital - Armour
  • Community Memorial Hospital - Burke
  • Sanford Canton-Inwood Medical Center - Canton
  • Sanford Chamberlain Medical Center - Chamberlain
  • Sanford Clear Lake Medical Center - Clear Lake
  • Sanford USD Medical Center - Sioux Falls
  • Sanford Vermillion Medical Center - Vermillion
  • Pioneer Memorial Hospital - Viborg
  • Sanford Webster Medical Center - Webster
  • Winner Regional Hospital - Winner
Independent Hospitals
  • Bowdle Hospital - Bowdle
  • Brookings Health System – Brookings
  • Faulkton Area Medical Center - Faulkton
  • Fall River Health Services - Hot Springs
  • Huron Regional Healthcare Center - Huron
  • Madison Community Hospital - Madison
  • Bennett Co Hospital - Martin
  • Mobridge Regional Hospital - Mobridge
  • Oyate Health Center - Rapid City
  • Prairie Lakes Healthcare System - Watertown