STI Resources for Healthcare Providers

Find information and resources about how to report various sexually transmitted infections (STIs) in South Dakota, including syphilis and congenital syphilis. For more information on treating and screening STIs, visit the CDC.

View Reportable Diseases & How to Report Find a Disease Intervention Specialist View the Monthly Disease Summaries

Upcoming STI Training

“At a Crossroads: The Syndemic of Syphilis, Substance Use, and Child Welfare During Pregnancy” 

April 16, 2024, 1:30 pm –3:00 pm CST.

This webinar serves as an opportunity to highlight the need for a syndemic approach to provide more holistic care to people who use substances and are considering pregnancy, pregnant, or postpartum.
  • The webinar will: Increase awareness on the syndemic interaction between substance use, syphilis, and policy during pregnancy and postpartum
  • Share best practices to provide more holistic prevention, treatment, and care to people who use substances and are considering pregnancy 
  • Identify policy solutions to address the syndemic of substance use, syphilis, and the challenges in accessing prenatal health care

Register Today

  1. STI Awareness Week – Syphilis, Congenital Syphilis, and Syphilis Cases Webinars (three opportunities to attend):
    April 16th, 2024 – 11am-12pm(CST) – Register
    April 17th, 2024 – 11am-12pm(CST) – Register
    April 18th, 2024 – 11am-12pm(CST) – Register

  2. ST. Louis PTC – STI Update Course 2023:
    April 25th, 2024 – 9am-12pm(CST) – Register

  3. St. Louis PTC – Clinical ELearning Collaborative 2023:
    May 30, 2024 – 12pm-1pm(CST) – Register

  4. St. Louis PTC – STI Intensive Course 2023:
    June 27th-28th, 2024 – 8am-4:30pm(CST) – Register

To view all of the courses, visit  

Thank you for your continued diligence and partnership in the mission to reduce the rates of STIs in South Dakota.

Extencilline Clinical Information

In January, Centers for Disease Control and Prevention (CDC) made aware that the U.S. Food and Drug Administration’s (FDA) announced the availability of Extencilline (benzathine benzylpenicillin injection, powder, for suspension) to address the ongoing shortages of Bicillin L-A®. At that time, CDC directed all to the FDA’s distribution and administration information in a letter to healthcare providers (see the “Dear Healthcare Provider Letter”). The preparation and administration of Extencilline, as well as the contraindications for prescribing, differ from those for Bicillin-LA®. CDC has provided a clinical information resource to more clearly delineate some of those differences and offer appropriate guidance. Please share this resource widely with your networks. 

Extencilline Information for Clinicians

Syphilis in South Dakota

From only 41 syphilis cases in 2016 to 1,351 in 2023, South Dakota has seen syphilis cases skyrocket in just a few years. The largest spike occurred between 2020’s 100 cases to 2021’s 874. As a health care provider, South Dakotans need your help. Learn how to reduce the rising syphilis rates with screening and testing.

Download Syphilis Healthcare Guidance:

Download Syphilis Infographics:

The Resurgence of Syphilis and Congenital Syphilis: What Do We Do Now?

SD-DOH and GPTLHB, in partnership with the STI Prevention Training Centers from the University of Washington in St. Louis, offered a free syphilis education session. The session is geared towards providers and focused on clinical care.

PDF | February 2, 2024