Kim Malsam-Rysdon, Secretary of Health

South Dakota Board of Pharmacy

Procedures for Opening a Pharmacy

Listed below are requirements to be followed in opening a new pharmacy.

Board of Pharmacy Requirements:  At least 30 days before the opening date the Application for Permit to Conduct a Pharmacy must be completed and sent with the fee to: South Dakota Board of Pharmacy, 3701 W. 49th St., Suite 204, Sioux Falls, SD 57106-3115.

Submit a blueprint or sketch of the new facility, including elevations showing consultation area.  Review rules for security, access and minimum equipment requirements.

Request an inspection of the new pharmacy by a Board of Pharmacy Inspector approximately two weeks prior to opening date.

South Dakota Department of Health Requirements:  Submit an application for a South Dakota Controlled Substances Certificate of Registration issued by the Health Department.  The Permit from the South Dakota State Board of Pharmacy must be obtained before submitting this application.  Apply to the department and the DEA at the same time. Submit this application to:  South Dakota Department of Health, Office of Health Care Facilities Licensure and Certification, Attention: Bob Coolidge, R.Ph., 615 E. Fourth St., Pierre, SD  57501-5070. Phone: 605-773-3356. Website:

Drug Enforcement Administration Requirements:  Submit an application for DEA registration (DEA Form-224).  If the application is submitted before the Pharmacy Permit is obtained, the applicant may enter “pending” in the appropriate area.   

The registrant transferring the pharmacy business to another registrant shall notify the nearest DEA Registration Field office at least 14 days before the proposed date of transfer and provide the following information:

  • The name, address and registration number of the registrant discontinuing business;
  • The name, address and registration number of the registrant acquiring the pharmacy;
  • Whether the business activities will be continued at the location registered by the current business owner or moved to another location.  It the latter, give the address of the new location.
  • The date on which the controlled substances will be transferred to the person acquiring the pharmacy.

Drug Enforcement Administration; Des Moines Resident Office; Federal Building, Room 937; 210 Walnut St., Des Moines, Iowa 50309. Phone:  515-284-4700. Website – 

Revised 1/08