Melissa Magstadt, South Dakota Secretary of Health


(mono, EBV mononucleosis)

South Dakota Department of Health
Office of Disease Prevention Services - 605-773-3737 — (1-800-592-1861 in South Dakota only)
This material is provided for informational purposes only and is not a substitute
for medical care. We are not able to answer personal medical questions. Please see your
health care provider concerning appropriate care, treatment or other medical advice.

What is infectious mononucleosis?
Infectious mononucleosis is a viral disease that affects certain blood cells. It is caused by the Epstein-Barr virus (EBV), which is a member of the herpes virus family. Most cases occur sporadically. Outbreaks are rare.

Who gets infectious mononucleosis?
While most people are exposed to the Epstein-Barr virus sometime in their lives, very few go on to develop the symptoms of infectious mononucleosis. In underdeveloped countries, people are exposed in early childhood where they are likely to develop noticeable symptoms. In developed countries such as the United States, the age first exposure may be delayed to older childhood and young adult age when symptoms are more likely to result. For this reason, it is recognized more often in high school and college students.

How is infectious mononucleosis spread?
The virus is spread by person-to-person contact, via saliva (on hands or toys, or by kissing). In rare instances the virus has been transmitted by blood transfusion.

What are the symptoms of infectious mononucleosis?
Symptoms include fever, sore throat, swollen glands and feeling tired. Sometimes the liver and spleen are affected. Duration is from one to several weeks. The disease is very rarely fatal.

How do symptoms appear?
Symptoms appear from four to six weeks after exposure.

When and for how long is a person able to spread infectious mononucleosis?
The virus is shed in the throat during the illness and for up to a year after infection. After the initial infection, the virus tends to become dormant for a prolonged period and can later reactivate and be shed from the throat again.

What is the treatment for infectious mononucleosis?
No treatment other than rest is needed in the vast majority of cases.

What can a person do to minimize the spread of infectious mononucleosis?
Avoid activities involving the transfer of body fluids (commonly saliva) with someone who is currently or recently infected with the disease. At present, there is no vaccine available to prevent infectious mononucleosis.

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