Joan Adam, Secretary of Health


Monkeypox: Visual examples of monkeypox rash. 4 photos. photo 1: palm of hand with purplish blisters like rash. Photo 2: Wrist with raised flesh-colored bump. Photo 3: Thumb with pimple-like blister. Photo 4: Back with raised inflamed blisters. Photo credit: NHS England High Consequence Infectious Disease Network. CDC Logo.

Monkeypox is a rare disease caused by an Orthopoxvirus, the same family as the virus that causes smallpox, however it is less severe. Persons with monkeypox in the current multi-country outbreak generally report having close, sustained physical contact with other people who have monkeypox. While many of those affected in the current global outbreaks are gay, bisexual, or other men who have sex with men, anyone who has been in close contact with someone who has monkeypox can get the illness. The risk to the general public is low.


  • Rash that looks like pimples or blisters that can occur in the mouth, genital and anal areas, or other parts of the face and body like the hands, feet, and chest.

  • Fever

  • Headache

  • Muscle and backaches

  • Chills

  • Exhaustion

  • Swollen Lymph Nodes

Case Counts

South Dakota Case Count: 1

U.S. Case Count (CDC)

CDC Monkeypox Website: Monkeypox disease information: symptoms, transmission, and treatment.


Take the following steps to prevent monkeypox:

  • Avoid close skin-to-skin contact with people who have a rash that looks like monkeypox

  • Do not handle or touch materials such as bedding, towels or clothing of a person with monkeypox

  • Wash your hands often with soap and water

CDC Resources:

For Clinicians




The antiviral medication tecovirimat (TPOXX) is available for the treatment of patients with monkeypox infection under the expanded access investigational new drug (EA-IND). Interested providers should follow the steps below:

  • Call the SD-DOH Epidemiology Team at 605-773-3737 to discuss the indication for treatment. Note: The primary indication for treatment has been lesions around the anus and genitals.
  • SD-DOH will work with the patient’s medical provider and CDC Monkeypox Clinical Team for a consultation since TPOXX is only available from the Strategic National Stockpile (SNS).
  • After consultation, the patient’s medical provider will confirm interest to continue under the EA-IND protocol and SD-DOH will assist with the order. The following information will be requested:
    • Shipping address
    • Point of Contact #1 (name, email, and 24/7 monitored phone number)
    • Point of Contact #2 (name, email, and 24/7 monitored phone number)
    • Route of Administration:  Oral or Intravenous
    • Days/Times the shipping address location is/is not available to receive shipment

  • Medical providers can anticipate TPOXX delivery from the SNS ~48 hours after the order is placed. There are no supplies of TPOXX pre-positioned in South Dakota.


If you have questions or would like additional information, please contact the Epidemiology team at 605-773-3737.

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