Kim Malsam-Rysdon, Secretary of Health

Get a Controlled Substance Registration

Contents: | How to get registered | Federal Drug Enforcement Agency Registration | Suspension of registration | US Drug Enforcement Agency

ATTENTION: After getting your controlled substance registration number, register with the South Dakota Prescription Drug Monitoring Program (SD PDMP). The South Dakota Department of Health supports practitioner participation in the SD PDMP program to improve patient care and reduce the misuse and abuse of controlled substances. Visit to learn how to register for an account in PMP AWARxE. If you have any questions about the SD PDMP, please contact Melissa DeNoon at the South Dakota Board of Pharmacy (605) 362-2737.

Who Needs a South Dakota Controlled Substance Registration
Practitioners listed below who dispense, administer, or prescribe controlled substances in South Dakota must have a South Dakota Controlled Substance Registration and federal Drug Enforcement Administration registration. Entities listed below who manufacture, use or distribute controlled substances in South Dakota must also have a South Dakota Controlled Substance Registration.


  • Physician
  • Veterinarian
  • Optometrist*
  • Nurse Practitioner**
  • Osteopathic Physician
  • Pharmacy***
  • Podiatrist
  • Dentist
  • Certified Nurse
  • Physician Assistant**
  • Manufacturer
  • Analytical Lab
  • Teaching Institution
  • Distributor
  • Animal Euthanasia
  • Researcher


*(South Dakota Codified Law) SDCL 36-7-1 limits optometrists to oral analgesics. This includes Schedule II Narcotic, Schedule III Narcotic, and Schedule IV.

**SDCL 36-9A (nurse practitioners) and SDCL 36-4A (physician assistants) grant specific prescriptive authority for controlled substances.

***Hospitals must have a licensed pharmacy (return to contents)

How to Get a South Dakota Controlled Substance Registration

  1. Download the appropriate controlled substance registration application.

    Physician Form - for medical doctor, osteopathic doctor, dentist, optometrist, pharmacy, veterinarian, podiatrist
    Mid-level Form - for nurse practitioner, physician assistant, nurse midwife
    Non-practitioner Form - for manufacturer, distributor, analytical lab, researcher (including drug detection dog trainers), animal euthanasia provider, teaching institution
    Request an application by e-mailing
    Request an application by writing to
    Bob Coolidge, R.Ph.
    South Dakota Department of Health
    Office of Health Care Facilities Licensure & Certification
    615 E. 4th Street
    Pierre, SD 57501-1700

  2. Complete the application and return it to the above address. See the instructions on the application form to determine the appropriate fee amount.

  3. New practitioners applying for a South Dakota Controlled Substance Registration in addition to a new Drug Enforcement Administration (DEA) registration can expect the process to take a minimum of six weeks.

  4. If you are moving your South Dakota practice location to another location in the state, you must notify the South Dakota Department of Health and the DEA prior to change of address. Change of address forms are available from the Department. (ARSD 44:58:06:02) Events causing automatic suspension of registration. The registration of a person is automatically suspended if the person fails to maintain the person's professional license, fails to maintain DEA registration in South Dakota, discontinues professional practice within South Dakota, or changes name or address without notifying the secretary. A practitioner who moves to a new location must request a modification of their registration.)

  5. If you are moving a federal DEA registration to South Dakota from another state, you must obtain a South Dakota Controlled Substance Registration and a valid South Dakota professional license. Registrant must also notify the DEA of the address change.

  6. Locum tenens practitioners registered in another state may obtain a locum tenens controlled substance registration, good for 60 days, based on their DEA registration from the state where they are licensed to practice.

Federal Drug Enforcement Administration Registration

Contact the federal Drug Enforcement Administration at 888-803-1179 for registration fees and application information for a DEA Controlled Substances Registration. (return to contents)

Suspension of a South Dakota Controlled Substance Registration

A South Dakota Controlled Substance Registration will be automatically suspended if the holder:

  • fails to maintain the appropriate professional license
  • fails to maintain DEA registration in South Dakota
  • discontinues professional practice in South Dakota changes name/ address without notifying the South Dakota Department of Health

U.S. Drug Enforcement Agency - Electronic Prescriptions for Controlled Substances

DEA Agent Supervising South Dakota:
Sarah Boblenz (515) 284-6644

Federal DEA Renewal Alert
Renewal Applications Online - Starting January 1, 2017, DEA will only send out one renewal notification in accordance with Title 21, Code of Federal Regulations, Section 1301.13(e)(3). The renewal notification will be sent to the “mail to” address for each DEA registrant approximately 65 days prior to the expiration date. No other reminders to renew the DEA registration will be mailed.

This is to also advise you that the online capability to renew a DEA registration after the expiration date will no longer be available. You will have to complete an application for a new DEA registration if you do not renew by midnight Eastern Time of the expiration date. The original DEA registration will not be reinstated.
Paper renewal applications will not be accepted the day after the expiration date. If DEA has not received the paper renewal application by the day of the expiration date, mailed in renewal applications will be returned and the registrant will have to apply for a new DEA registration.

DEA Form 224a - Retail Pharmacy, Hospital/Clinic, Practitioner, Teaching Institution, or Mid-Level Practitioner
DEA Form 225a - Manufacturer, Distributor, Researcher, Analytical Laboratory, Importer, Exporter

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