Kim Malsam-Rysdon, Secretary of Health

TB Medication

The South Dakota TB Control Program provides free medication for suspect and active TB cases as well as eligible high-risk persons diagnosed with latent TB infection who are residents of South Dakota. TB medication will only be provided with a written prescription by the patient’s physician and must be provided through a local Department of Health nurse.  All medication is processed and labeled through a contract pharmacy.  Health-care personnel who are requesting a patient be started on TB medications may call the local Office of Disease Prevention (Disease Intervention Offices) or the TB Control Program Coordinator at 605-773-3737 or 1-800-592-1861 (in-state only).  Listed below is the current South Dakota Department of Health TB medication formulary:

Medication Name Dosage
Tablets/capsules per bottle

Isoniazid (INH)

300 mg 

Isoniazid (INH) 100 mg
Liquid INH     50 mg/5 ml       
pint size bottle
Vitamin B-6 (pyridoxine) 50 mg    
Vitamin B-6 (pyridoxine) 25 mg      
Rifampin (RIF)         300 mg    
Rifampin (RIF)            150 mg                    
Pyrazinamide (PZA)  500 mg   
#60 and #90
Ethambutol (EMB)     400 mg    
#60 and #90
Ethambutol (EMB) 
100 mg     

Isoniazid 7

15 mg/kg rounded up to the nearest 50 or 100 mg;

900 mg maximum


10.0–14.0 kg 300 mg

14.1–25.0 kg 450 mg

25.1–32.0 kg 600 mg

32.1–49.9 kg 750 mg

          ≥50.0 kg 900 mg maximum

Isoniazid (INH) is formulated as 100 mg and 300 mg tablets. Rifapentine (RPT) is formulated as 150 mg tablets packed in blister packs that should be kept sealed until usage. New formulations with larger dosage per tablet and fixed-dose INH-RPT combinations are in development.

Source: Three months of weekly rifapentine and isoniazid for Mycobacterium tuberculosis infection (PREVENT TB). Information available at

The following TB medications are not maintained in the inventory and therefore are ONLY available by special order and may require additional shipping time to receive.

Medication Name
Tablets/capsules per bottle

Levofloxacin (Levaquin) 

500 mg

#50 and #100
Levofloxacin (Levaquin)  
750 mg
Moxifloxacin (Avelox) 
400 mg
1 g vials 
10 vials per box
Sterile water        
10 ml vials 
25 vials per box
Rifabutin (Mycobutin) 
150 mg  
Ethionamide (Trecator-SC)         
250 mg       
PAS (p-Aminosalicyclic Acid) (Paser)
4 g
30 granule packets per box
Cyclocerine (Ceromycin)        
250 mg      
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